Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) Lehto, Annaliis , 1996- (VerfasserIn) Prudlo, Johannes (AkademischeR BetreuerIn) Teipel, Stefan , 1970- (AkademischeR BetreuerIn) Bede, Peter (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2025 21.05.2025 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource (67 Seiten) Illustrationen, Diagramme The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Annaliis Lehto Enthält Zeitschriftenartikel Zeitschriftennachweis: Study I - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A, Kurth J, Krause B and Prudlo J (2024) Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis. Journal of Neurology 271: 5290-5300. https://doi.org/10.1007/s00415-024-12388-z ; Study II - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A and Prudlo J (2024) Loss of the ipsilateral silent period in amyotrophic lateral sclerosis is associated with reduced white matter integrity in the motor section of the corpus callosum. Journal of Neurological Sciences 466:123267. https://doi.org/10.1016/j.jns.2024.123267 ; Study III - Lehto A, Schumacher J, Kurth J, Krause B, Kasper E, Teipel S and Prudlo J (2025) Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. Journal of Neurology 272, 410. https://doi.org/10.1007/s00415-025-13089-x GutachterInnen: Johannes Prudlo (Universitätsmedizin Rostock) ; Stefan Teipel (Universitätsmedizin Rostock) ; Peter Bede (Trinity College Dublin) Dissertation Universität Rostock 2026 Kumulative Dissertation 150 610 https://purl.uni-rostock.de/rosdok/id00005757 Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)--(DE-627)1981971602 urn:nbn:de:gbv:28-rosdok_id00005757-5 doi: 10.18453/rosdok_id00005757 oclc: 1611896326 ppn: (DE-627)198197105X