E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma Interleukin 6 Dhar, Prabir , 1987- (VerfasserIn) Scheu, Stefanie (AkademischeR BetreuerIn) Murua Escobar, Hugo Istvan , 1973- (AkademischeR BetreuerIn) Mautner, Josef (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2025 April 2025 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource (IV, 86 Seiten) Illustrationen, Diagramme In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Prabir Dhar GutachterInnen: Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie) Dissertation Universität Rostock 2026 570 610 https://purl.uni-rostock.de/rosdok/id00005667 E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma--(DE-627)1979697183 urn:nbn:de:gbv:28-rosdok_id00005667-5 doi: 10.18453/rosdok_id00005667 oclc: 1606211497 ppn: (DE-627)1979689067