Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes Song, Zezhong , 1989- (VerfasserIn) Bader, Rainer , 1965- (AkademischeR BetreuerIn) Bertrand, Jessica , 1978- (AkademischeR BetreuerIn) Peters, Kirsten , 1966- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2024 June 2024 eng electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (V, 87 Seiten) Illustrationen, Diagramme In cell-based therapy for cartilage repair, preventing fibrocartilage formation due to dedifferentiation is crucial. This study examined how alternating electric fields affect the redifferentiation of human chondrocytes from male and female donors. Stimulation at 15–20 V/m increased the Col2/Col1 ratio and promoted rounded morphology, indicating enhanced redifferentiation. Meanwhile, female chondrocytes showed more collagen 1 production and fibroblast-like shape. These results suggest male chondrocytes showed higher tendency towards redifferentiation in response to electrical stimulation.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Zezhong Song GutachterInnen: Rainer Bader (Forschungslabor für Biomechanik und Implantattechnologie, Universität Rostock) ; Jessica Bertrand (Orthopädische Universitätsklinik mit Endoprothetikzentrum, Universitätsklinikum Magdeburg) ; Kirsten Peters (Center for Medical Research (ZEMFO), Institute of Cell Biology, Universität Rostock) Dissertation Universität Rostock 2025 570 610 616.7 610 https://purl.uni-rostock.de/rosdok/id00005205 https://doi.org/10.18453/rosdok_id00005205 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005205-6 https://d-nb.info/1394543700/34 Gender-specific impact of direct-coupled alternating electric fields on human chondrocytes--(DE-627)1966685114 urn:nbn:de:gbv:28-rosdok_id00005205-6 doi: 10.18453/rosdok_id00005205 oclc: 1579972014 ppn: (DE-627)1966684843