Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation Heat shock protein beta-8 chaperone-assisted selective autophagy fused in sarcoma chaperone-assisted selective autophagy-complex fused in sarcoma-aggregation Saleem, Kanza , 1991- (VerfasserIn) Hermann, Andreas , 1978- (AkademischeR BetreuerIn) Petri, Susanne , 1972- (AkademischeR BetreuerIn) Kipp, Markus , 1978- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2023 18.09.2023 eng ger electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (140 Seiten) Illustrationen, Diagramme Our research sheds light on the collaborative functioning of various chaperone systems within the proteostasis network. Molecular chaperones, including HSP70, and HSP40, and co-chaperones like HSC70, HSP90, and CHIP, are vital in protein quality control and degradation. Dysregulation within these systems, observed in HSPB8 knockout neurons, indicates impaired mechanisms for maintaining cellular proteostasis. This deficiency renders cells vulnerable to stress, resulting in detrimental effects on cellular survival.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Kanza Saleem GutachterInnen: Andreas Hermann (Universitätsmedizin Rostock) ; Susanne Petri (Klinik für Neurologie mit Klinischer Neurophysiologie) ; Markus Kipp (Universitätsmedizin Rostock) Dissertation Universität Rostock 2024 610 616.8 610 44.90 44.34 44.37 https://purl.uni-rostock.de/rosdok/id00004622 https://doi.org/10.18453/rosdok_id00004622 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004622-9 https://d-nb.info/1334986673/34 Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation--(DE-627)1892823349 urn:nbn:de:gbv:28-rosdok_id00004622-9 doi: 10.18453/rosdok_id00004622 oclc: 1443181923 ppn: (DE-627)189282163X