Protective role of gut commensal bacteria on epithelial barrier disruption and Ulcerative Colitis in vitro and in vivo Mohebali, Nooshin , 1986- (VerfasserIn) Kreikemeyer, Bernd , 1966- (AkademischeR BetreuerIn) Basen, Mirko (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Mathematisch-Naturwissenschaftliche Fakultät (Grad-verleihende Institution) Text theses Text Hochschulschrift 2023 2023 eng ger electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (XIV, 128 Seiten) Illustrationen, Diagramme This study investigates the role of three commensal bacteria - Faecalibacterium prausnitzii, Bacteroides faecis, and Roseburia intestinalis - in maintaining intestinal barrier integrity and their potential to mitigate chronic inflammation, with a focus on Ulcerative Colitis (UC). Using in vitro and in vivo models, the study demonstrates that these bacteria alleviate inflammatory-induced impairment of the intestinal barrier, enhance barrier function, and mitigate pro-inflammatory processes.<eng> Open Access Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International vorgelegt von Nooshin Mohebali GutachterInnen: Bernd Kreikemeyer (Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsmedizin Rostock) ; Mirko Basen (Institut für Biowissenschaften, Universität Rostock) Dissertation Universität Rostock 2024 500 616.3 610 https://purl.uni-rostock.de/rosdok/id00004620 https://doi.org/10.18453/rosdok_id00004620 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004620-5 https://d-nb.info/1334986649/34 Protective role of gut commensal bacteria on epithelial barrier disruption and Ulcerative Colitis in vitro and in vivo--(DE-627)1892728540 urn:nbn:de:gbv:28-rosdok_id00004620-5 doi: 10.18453/rosdok_id00004620 oclc: 1443003395 ppn: (DE-627)1892728079