Method improvements for real-time mass spectrometric monitoring of exhaled VOCs in the clinical environment Pugliese, Giovanni , 1988- (VerfasserIn) Schubert, Jochen , 1956- (AkademischeR BetreuerIn) Fischer, Dagmar-Christiane , 1959- (AkademischeR BetreuerIn) Mayhew, Christopher Anthony (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2020 2020 eng electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (verschiedene Seitenzählungen) Illustrationen, Diagramme We improved the measurement capabilities of PTR-MS for real-time monitoring of breath VOCs in the clinical environment. In the first study, we evaluated the effects of a modular ion-funnel onto PTR-MS performances in terms of sensitivity and LODs. In the second study we optimized instrumental conditions for direct breath-resolved real-time monitoring of highly reactive compounds. In the third study, we evaluated the effects of potential confounders from the clinical environment such as elevated inspired O2 concentrations onto PTR-MS based VOC analysis.<eng> Open Access Urheberrechtsschutz 1.0 presented by Giovanni Pugliese Enthält Zeitschriftenbeiträge GutachterInnen: Jochen Klaus Schubert (Universitätsmedizin Rostock, Klinik und Poliklinik für Anästhesiologie und Intensivtherapie), Dagmar-Christiane Fischer (Universitätsmedizin Rostock, Klinik und Poliklinik Kinder- und Jugendmedizin), Christopher Anthony Mayhew (Leopold-Franzens-Universität Innsbruck, Institut für Atemgasanalytik) Zeitschriftennachweis: 1) Effects of modular ion-funnel technology onto analysis of breath VOCs by means of real-time mass spectrometry. Pugliese Giovanni, Piel Felix, Trefz Phillip, Sulzer Philipp, Schubert Jochen Klaus, Miekisch Wolfram. Analytical Bioanalytical Chemistry 2020; 412, 7131–7140. ISSN:1618-2650. DOI: https://doi.org/10.1007/s00216-020-02846-8. 2) Extending PTR based breath analysis to real-time monitoring of reactive volatile organic compounds. Pugliese Giovanni, Trefz Phillip, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Analyst 2019; 144, 7359–7367. ISSN: 1364-5528. DOI: https://doi.org/10.1039/C9AN01478K. 3) Effects of elevated oxygen levels on VOC analysis by means of PTR-ToF-MS. Trefz Phillip, Pugliese Giovanni, Brock Beate, Schubert Jochen Klaus, Miekisch Wolfram. Journal of Breath Research 2019; 13(4):046004. ISSN: 1752-7163. DOI: 10.1088/1752-7163/ab28ec Dissertation Universität Rostock 2021 Kumulative Dissertation 500 540 610 616.994 610 44.09 https://purl.uni-rostock.de/rosdok/id00004596 https://doi.org/10.18453/rosdok_id00004596 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004596-4 https://d-nb.info/1332620930/34 Method improvements for real-time mass spectrometric monitoring of exhaled VOCs in the clinical environment--(DE-627)1767509014 urn:nbn:de:gbv:28-rosdok_id00004596-4 doi: 10.18453/rosdok_id00004596 oclc: 1436705082 ppn: (DE-627)1890429449