Phosphoproteome analysis of the near-haploid cell line HAP1 reveals phosphorylation events originating from PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK) Albony, Hasan , 1981- (VerfasserIn) Thiesen, Hans-Jürgen , 1956- (AkademischeR BetreuerIn) Gerner, Christopher (AkademischeR BetreuerIn) Murua Escobar, Hugo Istvan , 1973- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2021 29.04.2021 eng electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (III, 126 Seiten) Illustrationen, Diagramme PBK is a serine/threonine kinase. During mitosis, PBK phosphorylates the inter-zinc finger linker sequence (TGEKP) of hundreds of C2H2 zinc finger proteins and liberates these transcription factors from the condensing chromatin. This study aimed to investigate PBK-dependent phosphorylation events by analyzing the phosphoproteome of both wild and PBK knockout HAP1 cells. The analysis identified candidates belong to DNA- and RNA binding proteins (ADNP and FUBP1) or dynamic regulators of cell organelles (MARCKS and PGRMC1).<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Hasan Albony GutachterInnen: Hans-Jürgen Thiesen (Institut für Immunologie, Universität Rostock) ; Christopher Gerner (Fakultät für Chemie, Universität Wien) ; Hugo Murua Escobar (Medizinische Klinik III, Universität Rostock) Dissertation Universität Rostock 2022 570 571.84 570 XD 2904 XD 3304 44.45 https://purl.uni-rostock.de/rosdok/id00004478 https://doi.org/10.18453/rosdok_id00004478 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004478-9 https://d-nb.info/1313002321/34 Phosphoproteome analysis of the near-haploid cell line HAP1 reveals phosphorylation events originating from PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK)--(DE-627)1832389812 urn:nbn:de:gbv:28-rosdok_id00004478-9 doi: 10.18453/rosdok_id00004478 oclc: 1412000751 ppn: (DE-627)1872125352