Elucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combination Lupu, Loredana-Mirela , 1992- (VerfasserIn) Tiedge, Markus , 1963- (AkademischeR BetreuerIn) Glocker, Michael , 1960- (AkademischeR BetreuerIn) Przybylski, Michael , 1948-2023 (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2022 2022 eng electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (getrennte Zählung) Illustrationen, Diagramme The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Loredana-Mirela Lupu Enthält Zeitschriftenartikel GutachterInnen: Markus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem) Dissertation Universität Rostock 2023 Kumulative Dissertation 500 615.19 610 35.78 42.13 https://purl.uni-rostock.de/rosdok/id00004458 https://doi.org/10.18453/rosdok_id00004458 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004458-6 https://d-nb.info/1309753776/34 Elucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combination--(DE-627)1869705734 urn:nbn:de:gbv:28-rosdok_id00004458-6 doi: 10.18453/rosdok_id00004458 oclc: 1408381628 ppn: (DE-627)1869704800