Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols Offer, Svenja Hannah , 1992- (VerfasserIn) Zimmermann, Ralf , 1963- (AkademischeR BetreuerIn) Rothen-Rutishauser, Barbara (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Mathematisch-Naturwissenschaftliche Fakultät (Grad-verleihende Institution) Text theses Text Hochschulschrift 2023 Februar 2023 eng ger electronic resourceremoteComputermedienOnline-Ressourceapplication/pdf1 Online-Ressource (getrennte Zählung) Illustrationen, Diagramme This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.<eng> Open Access Urheberrechtsschutz 1.0 vorgelegt von Svenja Hannah Offer Enthält Zeitschriftenartikel GutachterInnen: Ralf Zimmermann (Institut für Chemie, Universität Rostock) ; Barbara Rothen-Rutishauser (Adolphe Merkle Institut, Universität Fribourg, Schweiz) Dissertation Universität Rostock 2023 Kumulative Dissertation 500 540 570 610.28 610 VE 7097 43.12 http://purl.uni-rostock.de/rosdok/id00004409 https://doi.org/10.18453/rosdok_id00004409 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004409-8 https://d-nb.info/130101673X/34 Cellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosols--(DE-627)1857866436 urn:nbn:de:gbv:28-rosdok_id00004409-8 doi: 10.18453/rosdok_id00004409 oclc: 1395066104 ppn: (DE-627)1857865693