Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells Shokraie, Fatemeh , 1982- (VerfasserIn) Zechner, Dietmar , 1969- (AkademischeR BetreuerIn) Prall, Friedrich , 1964- (AkademischeR BetreuerIn) Kersting, Stephan , 1973- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2021 2021 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource The mortality rate in colorectal cancer patients is still high. One of the main consequences of treatment failure is tumor relapse. It is presumed that cancer stem cells (CSCs) are the cause of cancer recurrence and metastasis due to their cellular plasticity. These cells are capable to evade the immune system and endure nutritional deprivation, resulting in CSCs survival after treatment and restoring tumor growth after cancer cell elimination. Thus, precise characterization, successful targeting, and eradication of CSCs can improve cancer treatment.<eng> vorgelegt von Fatemeh Shokraie GutachterInnen: Dietmar Zechner (Rudolf-Zenker-Instituts für Experimentelle Chirurgie, Universitätsmedizin Rostock) ; Friedrich Prall (Institut für Pathologie, Universitätsmedizin Rostock) ; Stephan Kersting (Klinik und Poliklinik für Allgemeine Chirurgie, Universität Greifswald) Dissertation Universität Rostock 2022 570 610 616.994 610 YC 5389 XH 3504 XH 7212 44.81 44.61 44.65 http://purl.uni-rostock.de/rosdok/id00003975 https://doi.org/10.18453/rosdok_id00003975 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003975-5 https://d-nb.info/1293538892/34 Defining the role of human endogenous retroviruses in pluripotency of colorectal cancer cells--(DE-627)1820243869 urn:nbn:de:gbv:28-rosdok_id00003975-5 doi: 10.18453/rosdok_id00003975 oclc: 1347098790 ppn: (DE-627)1818361930