Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human Butenko, Konstantin , 1994- (VerfasserIn) Rienen, Ursula van , 1957- (AkademischeR BetreuerIn) Köhling, Rüdiger , 1966- (AkademischeR BetreuerIn) Lowery, Madeleine (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Fakultät für Informatik und Elektrotechnik (Grad-verleihende Institution) Text theses Text Hochschulschrift 2021 2021 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource Deep brain stimulation is an established treatment for Parkinson’s disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.<eng> vorgelegt von Konstantin Butenko GutachterInnen: Ursula van Rienen (Universität Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Madeleine Lowery (University College Dublin) Dissertation Universität Rostock 2022 620 616.8 610 http://purl.uni-rostock.de/rosdok/id00003623 https://doi.org/10.18453/rosdok_id00003623 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003623-9 https://d-nb.info/1293537381/34 Modeling perspective on translatability of deep brain stimulation mechanism for treating Parkinsonian motor symptoms in rodent and human--(DE-627)1800251807 urn:nbn:de:gbv:28-rosdok_id00003623-9 doi: 10.18453/rosdok_id00003623 oclc: 1312334517 ppn: (DE-627)1799953491