Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells Lu, Lili , 1992- (VerfasserIn) Linnebacher, Michael , 1969- (AkademischeR BetreuerIn) Ramer, Robert Georg , 1971- (AkademischeR BetreuerIn) Krämer, Oliver H. (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2021 2021 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource The present study aimed at 1) testing the sensitivity of CRC cell lines with defined molecular alterations to curcumin; 2) mechanistically analyzing sensitive CRC cell lines in order to identify the mode-of-action; 3) identifying biomarkers associated with curcumin sensitivity; 4) establishing a predictive model using biomarkers to predict the sensitivity of additional CRC cell line to curcumin.<eng> vorgelegt von Lili Lu GutachterInnen: Michael Linnebacher (Molekulare Onkologie und Immuntherapie, Allgemeine Chirurgie, Universitätsmedizin Rostock) ; Robert Ramer (Institut für Pharmakologie und Toxikologie, Universitätsmedizin Rostock) ; Oliver H. Krämer (Institut für Toxikologie, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz) Dissertation Universität Rostock 2021 500 610 616.994 610 XH 7217 44.81 44.87 http://purl.uni-rostock.de/rosdok/id00003164 https://doi.org/10.18453/rosdok_id00003164 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003164-0 https://d-nb.info/1293534625/34 Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells--(DE-627)1772810185 urn:nbn:de:gbv:28-rosdok_id00003164-0 doi: 10.18453/rosdok_id00003164 oclc: 1268469961 ppn: (DE-627)177105252X