Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway Shang, Yuru , 1988- (VerfasserIn) Zechner, Dietmar , 1969- (AkademischeR BetreuerIn) Wiegering, Armin , 1981- (AkademischeR BetreuerIn) Linnebacher, Michael , 1969- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2021 2021 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.<eng> vorgelegt von Yuru Shang GutachterInnen: Dietmar Zechner (Rudolf-Zenker-Institut für Experimentelle Chirurgie, Zentrale Versuchstierhaltung Multimodale Kleintierbildgebung) ; Armin Wiegering (Universitätsklinikum Würzburg, Zentrum Operative Medizin, Klinik und Poliklinik für Allgemein- und Viszeralchirurgie, Gefäß- und Kinderchirurgie) ; Michael Linnebacher (Universitätsmedizin Rostock, Molekulare Onkologie und Immuntherapie, Allgemeine Chirurgie) Dissertation Universität Rostock 2021 570 610 616.994 610 XH 7215 44.81 http://purl.uni-rostock.de/rosdok/id00003037 https://doi.org/10.18453/rosdok_id00003037 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003037-4 https://d-nb.info/1293663751/34 Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway--(DE-627)1759893897 urn:nbn:de:gbv:28-rosdok_id00003037-4 doi: 10.18453/rosdok_id00003037 oclc: 1253757676 ppn: (DE-627)1759758876