Stressors modulating granulosa cell functionality, ovulation and oocyte competence in bovines Sharma, Arpna , 1987- (VerfasserIn) Braun, Beate , 1974- (AkademischeR BetreuerIn) Pfarrer, Christiane (AkademischeR BetreuerIn) Vanselow, Jens , 1960- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Mathematisch-Naturwissenschaftliche Fakultät (Grad-verleihende Institution) Text theses Text Hochschulschrift 2020 2020 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource Ovarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.<eng> vorgelegt von ARPNA Sharma Enthält Zeitschriftenartikel GutachterInnen: Beate Brown (Reproductive Biology, Leibniz Institute for Zoo and Wildlife Research (IZW) Berlin) ; Christiane Pastor (Veterinary University Hannover, Anatomical Institute) ; Jens Vanselow (Leibniz Institute for Livestock Biology (FBN) Dummerstorf) Dissertation Universität Rostock 2021 Kumulative Dissertation 570 ZD 32100 48.60 http://purl.uni-rostock.de/rosdok/id00002985 https://doi.org/10.18453/rosdok_id00002985 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002985-6 https://d-nb.info/1293533955/34 Stressors modulating granulosa cell functionality, ovulation and oocyte competence in bovines--(DE-627)1752657675 urn:nbn:de:gbv:28-rosdok_id00002985-6 doi: 10.18453/rosdok_id00002985 oclc: 1244452130 ppn: (DE-627)1752313488