Antiarrhythmic effect of human bone marrow-dereived CD271+ mesenchymal stem cells tested in vivo using a new infarction-re-infarction mouse model Sadraddin, Haval Lutfalla , 1985- (VerfasserIn) Stamm, Christof (AkademischeR BetreuerIn) Steinhoff, Gustav , 1958- (AkademischeR BetreuerIn) Vollmar, Brigitte , 1961- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2019 2019 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource This experiment showed the safety and antiarrhythmic effect of human bone marrow-derived CD271+ MSC. This was performed in immune deficient mice (Rag2-/-γc-/--mice) with electrocardiogram monitoring through Implantation of telemtry system. The induction of ventricular arrhythmias has been achieved via a permanent re-infarction through left anterior descending artery (LAD) ligation one week after a 30-minute ischemia-reperfusion. The time between 2 infarctions gave the stem cells the required period to entgraft themselves after their intramyocardial injection with the first infarction.<eng> vorgelegt von Haval Lutfalla Sadraddin GutachterInnen: Christof Stamm (Deutsches Herzzentrum Berlin, BIH Center for Regenerative Therapies, Charite Universitätsmedizin) ; Gustav Steinhoff (Universitätsmedizin Rostock, Klinik und Poliklinik für Herzchirurgie) ; Brigitte Vollmar (Universitätsmedizin Rostock, Rudolf-Zenker-Institut für Experimentelle Chirurgie) Dissertation Universität Rostock 2021 610 616.1 610 YB 9512 44.85 http://purl.uni-rostock.de/rosdok/id00002970 https://doi.org/10.18453/rosdok_id00002970 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002970-5 https://d-nb.info/129366278X/34 Antiarrhythmic effect of human bone marrow-dereived CD271+ mesenchymal stem cells tested in vivo using a new infarction-re-infarction mouse model--(DE-627)1751194108 urn:nbn:de:gbv:28-rosdok_id00002970-5 doi: 10.18453/rosdok_id00002970 oclc: 1240421457 ppn: (DE-627)175043959X