Proteome profiling of maternal serum: a novel approach for intrauterine growth restriction screening during pregnancy Okai, Charles Ayensu , 1974- (VerfasserIn) Glocker, Michael , 1960- (AkademischeR BetreuerIn) Pecks, Ulrich , 1975- (AkademischeR BetreuerIn) Murua Escobar, Hugo Istvan , 1973- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2020 2020 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource Fetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.<eng> vorgelegt von Charles Ayensu Okai GutachterInnen: Michael O. Glocker (Universität Rostock, Proteom Zentrum Rostock) ; Ulrich Pecks (Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe) ; Hugo Murua Escobar (Universität Rostock, Zentrum für Innere Medizin, Medizinische Klinik III - Hämatologie, Onkologie, Palliativmedizin) Dissertation Universität Rostock 2020 540 570 610 618.3 610 YM 5817 35.76 44.92 http://purl.uni-rostock.de/rosdok/id00002801 https://doi.org/10.18453/rosdok_id00002801 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002801-9 https://d-nb.info/1293661325/34 Proteome profiling of maternal serum--(DE-627)1738546640 urn:nbn:de:gbv:28-rosdok_id00002801-9 doi: 10.18453/rosdok_id00002801 oclc: 1226325082 ppn: (DE-627)1738299295