Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells: role of the anti-oxidative enzyme heme oxygenase-1 Schwartz, Margit , 1986- (VerfasserIn) Hinz, Burkhard , 1967- (AkademischeR BetreuerIn) Rauch, Bernhard (AkademischeR BetreuerIn) Kraft, Karin , 1952- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universitätsmedizin Rostock (Grad-verleihende Institution) Text theses Text Hochschulschrift 2018 2018 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.<eng> vorgelegt von Margit Schwartz GutachterInnen: Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde) Dissertation Universität Rostock 2019 570 610 612.01 610 XI 5104 44.38 http://purl.uni-rostock.de/rosdok/id00002522 https://doi.org/10.18453/rosdok_id00002522 https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002522-0 https://d-nb.info/1293657557/34 Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells--(DE-627)1671834267 urn:nbn:de:gbv:28-rosdok_id00002522-0 doi: 10.18453/rosdok_id00002522 oclc: 1135661028 ppn: (DE-627)167175865X