Differentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogels Liedmann, Andrea , 1979- (VerfasserIn) Rolfs, Arndt , 1959- (AkademischeR BetreuerIn) Kuznetsov, Sergei A. (AkademischeR BetreuerIn) Wree, Andreas , 1952- (AkademischeR BetreuerIn) Universität Rostock (Grad-verleihende Institution) Universität Rostock Mathematisch-Naturwissenschaftliche Fakultät (Grad-verleihende Institution) Text theses Text Hochschulschrift 2013 2013 eng electronic resourceremoteComputermedienOnline-Ressource1 Online-Ressource In this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.<eng> vorgelegt von Andrea Liedmann GutachterInnen: Arndt Rolfs (Universität Rostock, Albrecht-Kossel-Institut für Neuroregeneration (AKos), Zentrum für Nervenheilkunde) ; Sergei A. Kuznetsov (Institut für Zellbiologie und Biosystemtechnik, Fachbereich Biowissenschaften) ; A. Wree (Universitätsmedizin Rostock, Institut für Anatomie) Dissertation Universität Rostock 2013 610 570 WW 3880 WX 6640 42.15 44.90 http://purl.uni-rostock.de/rosdok/id00002503 Differentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogels--(DE-627)1670228428 urn:nbn:de:gbv:28-rosdok_id00002503-3 doi: 10.18453/rosdok_id00002503 oclc: 1135503201 ppn: (DE-627)1669963233