@Book{865502897,
author="Hofrichter, Jacqueline",
title="influence of plant  extracts on $\beta$-Amyloid induced pathologies in an APP/PS1 mouse model of Alzheimer's disease",
year="2014",
address="Rostock",
abstract="The study explored the influence of plant extracts on neuronal degeneration caused by toxic $\beta$-amyloid in a transgenic APP/PS1 mouse model of Alzheimer`s disease. Daily oral application of extracts of Hypericum perforatum and Sideritis spp. attenuated A$\beta$-induced histopathology and alleviated memory impairments in APP/PS1 mice. In detail, both extracts (i) decreased intracerebral A$\beta$42 and (ii) A$\beta$ plaques, (iii) rescued neocortical neurons, and (iv) restored cognition to healthy control levels due to an enhanced A$\beta$42 export activity of ABCC1 and an increased phagocytic microglia activity.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von: Jacqueline Hofrichter",
note="Dissertation Universit{\"a}t Rostock 2014",
url="http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0083-8",
language="English"
}