@Book{865456275,
author="Haack, Fiete",
title="Exploring the spatio-temporal dynamics of lipid rafts and their role in signal transduction: a modeling and simulation approach",
year="2015",
address="Rostock",
abstract="The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/$\beta$-catenin signaling is explored by means of an integrated in silico and in vitro approach.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von: Fiete Haack aus Rostock",
note="Dissertation Universit{\"a}t Rostock 2016",
url="http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2016-0080-1",
language="English"
}