@Book{856304654,
author="Schade, Anna",
title="MicroRNA-based stem cell modifications using magnetic transfection complexes: a non-viral approach towards cardiac regeneration = MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe : ein nicht-viraler Ansatz f{\"u}r die kardiale Regeneration = MikroRNA-basierte Stammzellmodifikationen mittels magnetischer Transfektionskomplexe",
year="2015",
address="Rostock",
abstract="Regenerative properties of human mesenchymal stem cells (hMSC) can be enhanced by genetic modifications. Thus we aimed to develop a magnetic non-viral vector for microRNA (miR) delivery in freshly isolated hMSCs. miR/PEI/MNP transfection showed a better long term performance compared to miR/PEI transfection. Moreover magnetically modified hMSCs could be guided by an external magnet contributing to enhanced cell engraftment. Conclusively a magnetic non-viral carrier for efficient miR delivery in freshly isolated hMSCs was developed allowing specific control of stem cells and magnetic targeting.<eng>",
school="Universit{\"a}t Rostock",
note="submitted by: Anna Schade (geborene Sponholz), from Rostock",
note="Dissertation Universit{\"a}t Rostock 2015",
url="http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2015-0234-1",
language="English"
}