@Book{782499139,
author="Lao, Angelyn",
title="systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease",
year="2012",
abstract="In this dissertation APP processing is modelled and the influence of SORLA in Alzheimer's disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects $\beta$-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase.",
note="vorgelegt von Angelyn Lao",
note="Enth. Poster",
note="Rostock, Univ., Fak. f{\"u}r Informatik und Elektrotechnik, Diss., 2013",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0075-4&pdf",
url="http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0075-4",
language="English"
}