@Book{779622480,
author="Schmitz, Yvonne",
title="Compartmental modelling of the Wnt pathway: elucidating the role of nucleo-cytoplasmic shuttling of $\beta$-catenin and its antagonists",
year="2013",
abstract="The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.",
note="vorgelegt von Yvonne Schmitz",
note="Rostock, Univ., Fak. f{\"u}r Informatik und Elektrotechnik, Diss., 2013",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2014-0055-2&pdf",
url="http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2014-0055-2",
language="English"
}