@Book{684559005,
author="Mazemondet, Orianne",
title="Spatio-temporal dynamics of the Wnt/$\beta$-catenin signaling pathway: a computational systems biology approach",
year="2011",
abstract="The Wnt/{\ss}-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.",
note="vorgelegt von Orianne Mazemondet",
note="Rostock, Univ., Fak. f{\"u}r Informatik und Elektrotechnik, Diss., 2011",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4",
url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2012-0005-4&pdf",
url="http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2012-0005-4",
language="English"
}