@Book{59268413X, author="Schwarz, Nicolle", title="Synthesis and catalytic functionalization of biologically active indoles", year="2008", abstract="Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized.", note="vorgelegt von Nicolle Schwarz", note="Rostock, Univ., Mathematisch-Naturwiss. Fak., Diss., 2008", url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0", url="http://rosdok.uni-rostock.de/resolve?urn=urn:nbn:de:gbv:28-diss2009-0035-0&pdf", url="http://nbn-resolving.de/urn:nbn:de:gbv:28-diss2009-0035-0", language="English" }