@Book{1984314068,
author="Su, Zhaoran",
title="NAALADL1 as a key modulator of resistance to Tumor Treating Fields therapy in colorectal cancer",
year="2025",
address="Germany; Rostock",
abstract="Colorectal cancer (CRC) shows heterogeneous responses to Tumor Treating Fields (TTF), a non-invasive therapy disrupting mitosis. In 21 CRC cell lines, TTF induced microtubule disruption, mitotic defects, metabolic stress, DNA damage, and apoptosis. NAALADL1 was upregulated in resistant cells; its knockdown enhanced TTF sensitivity by stabilizing microtubules and inducing G2/M arrest. Virtual screening identified Lumacaftor and Bestatin as synergistic with TTF, highlighting NAALADL1 as a promising target for personalized CRC therapy.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Zhaoran Su",
note="GutachterInnen: Michael Linnebacher (Klinik und Poliklinik f{\"u}r Allgemein-, Viszeral-, Thorax-, Gef{\"a}{\ss}- und Transplantationschirurgie, Universit{\"a}tsmedizin Rostock) ; Hugo Murua Escobar (Institut und Poliklinik f{\"u}r Medizinische Genetik, Universit{\"a}tsmedizin Rostock) ; Oliver H. Kr{\"a}mer (Department of Toxicology, Johannes Gutenberg University Mainz)",
note="Dissertation Universit{\"a}t Rostock 2026",
doi="10.18453/rosdok_id00005800",
url="https://purl.uni-rostock.de/rosdok/id00005800",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00005800-2",
url="https://d-nb.info/1420686534/34",
url="https://doi.org/10.18453/rosdok_id00005800",
language="English"
}