@Book{1979689067,
author="Dhar, Prabir",
title="E2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanoma",
year="2025",
address="Germany; Rostock",
abstract="In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Prabir Dhar",
note="GutachterInnen: Stefanie Scheu (Universit{\"a}tsmedizin Rostock, Institut f{\"u}r Immunologie) ; Hugo Murua Escobar (Universit{\"a}tsmedizin Rostock, Institut f{\"u}r Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum M{\"u}nchen, Institut f{\"u}r Virologie)",
note="Dissertation Universit{\"a}t Rostock 2026",
doi="10.18453/rosdok_id00005667",
url="https://purl.uni-rostock.de/rosdok/id00005667",
url="https://doi.org/10.18453/rosdok_id00005667",
language="English"
}