@Book{1928914721,
author="Berthold, Anne",
title="Epigenetic studies in bovine mastitis cell models",
year="2024",
address="Rostock",
abstract="This study focused on histone modifications and their role in epithelial cell models MAC-T and pbMEC exposed to mastitis pathogens Escherichia coli and Staphylococcus aureus. Main insights were gained by molecular techniques, including N-ChIP-qPCR, RNA-seq, and X-ChIP-seq. Both cell types upregulated immune genes in response to pathogen contact. The findings revealed significantly different gene expression and peaks for H3K4me3 and H3K27me3 between MAC-T and pbMEC. Moreover, the genome-wide data indicated epigenetic control of upregulated genes after the Escherichia coli challenge in pbMEC.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Anne Berthold",
note="GutachterInnen: Reinhard Schr{\"o}der (Universit{\"a}t Rostock, Mathematisch-Naturwissenschaftliche Fakult{\"a}t, Institut f{\"u}r Biowissenschaften, Abt. Genetik) ; Christa K{\"u}hn (Universit{\"a}t Rostock, Agrar- und Umweltwissenschatliche Fakult{\"a}t, Abt. Genetik der Krankheitsresistenz) ; Jens Tetens (Georg-August-Universit{\"a}t G{\"o}ttingen, Department f{\"u}r Nutztierwissenschaften, Abt. Functional Breeding)",
note="Dissertation Universit{\"a}t Rostock 2024",
doi="10.18453/rosdok_id00004844",
url="https://purl.uni-rostock.de/rosdok/id00004844",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004844-8",
url="https://d-nb.info/1370896042/34",
url="https://doi.org/10.18453/rosdok_id00004844",
language="English"
}