@Book{189282163X,
author="Saleem, Kanza",
title="Loss-Of HSPB8 leads to prolonged stress granules disassembly via impaired CASA-complex ultimately causing FUS-aggregation",
year="2023",
address="Rostock",
abstract="Our research sheds light on the collaborative functioning of various chaperone systems within the proteostasis network. Molecular chaperones, including HSP70, and HSP40, and co-chaperones like HSC70, HSP90, and CHIP, are vital in protein quality control and degradation. Dysregulation within these systems, observed in HSPB8 knockout neurons, indicates impaired mechanisms for maintaining cellular proteostasis. This deficiency renders cells vulnerable to stress, resulting in detrimental effects on cellular survival.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Kanza Saleem",
note="GutachterInnen: Andreas Hermann (Universit{\"a}tsmedizin Rostock) ; Susanne Petri (Klinik f{\"u}r Neurologie mit Klinischer Neurophysiologie) ; Markus Kipp (Universit{\"a}tsmedizin Rostock)",
note="Dissertation Universit{\"a}t Rostock 2024",
doi="10.18453/rosdok_id00004622",
url="https://purl.uni-rostock.de/rosdok/id00004622",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004622-9",
url="https://d-nb.info/1334986673/34",
url="https://doi.org/10.18453/rosdok_id00004622",
language="English"
}