@Book{1887560912,
author="M{\"u}ller-Eigner, Annika",
title="Assessing the impact of sodium butyrate and a light-activated proton pump on energy metabolism and lifespan of Drosophila melanogaster and Caenorhabditis elegans",
year="2023",
address="Rostock",
abstract="In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Annika M{\"u}ller-Eigner",
note="GutachterInnen: Reinhard Schr{\"o}der (Universit{\"a}t Rostock, Mathematisch-Naturwissenschaftliche Fakult{\"a}t) ; Shahaf Peleg (FBN Dummerstorf) ; Tom Goldammer (FBN Dummerstorf, Agrar- und Umweltwissenschaftliche Fakult{\"a}t)",
note="Dissertation Universit{\"a}t Rostock 2023",
doi="10.18453/rosdok_id00004576",
url="https://purl.uni-rostock.de/rosdok/id00004576",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004576-2",
url="https://d-nb.info/1329239512/34",
url="https://doi.org/10.18453/rosdok_id00004576",
language="English"
}