@Book{1877357669,
author="Sueto, Salem Oduro Beffi",
title="Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction",
year="2023",
address="Rostock",
abstract="The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Salem Odura Beffi Sueto",
note="GutachterInnen: Georg Fuellen (Institut f{\"u}r Biostatistik und Informatik in Medizin und Alternsforschung, Universit{\"a}t Rostock) ; Michael Walter (Institut f{\"u}r Klinische Chemie und Laboratoriumsmedizin, Universit{\"a}t Rostock) ; Dirk Repsilber (Functional Bioinformatics, {\"O}rebro University, {\"O}rebro, Sweden)",
note="Dissertation Universit{\"a}t Rostock 2023",
doi="10.18453/rosdok_id00004514",
url="https://purl.uni-rostock.de/rosdok/id00004514",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004514-9",
url="https://d-nb.info/1315379406/34",
url="https://doi.org/10.18453/rosdok_id00004514",
language="English"
}