@Book{1857757386,
author="Salewski, Inken",
title="Combined immunotherapy approaches in preclinical models of mismatch-repair-deficiency-associated tumorigenesis",
year="2023",
address="Rostock",
abstract="In this thesis, different immunotherapy strategies we employed to combat mismatch-repair-deficient (dMMR) cancer. We used two preclinical mouse models, either having constitutional (Mlh1) or conditional (Msh2) knock out. To prevent resistance development and improve outcome, we focused on combination strategies including whole tumor vaccines, immune checkpoint-inhibitors ($\alpha$-PD-L1), classical chemotherapy or the Cyclin-dependent kinase inhibitor abemaciclib. By applying different combination strategies, a significant survival benefit was reached in all investigated treatments.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Inken Salewski",
note="Enth{\"a}lt Zeitschriftenartikel",
note="GutachterInnen: Ulrike Gimsa (Universit{\"a}t Rostock, Forschungsinstitut f{\"u}r Nutztierbiologie, Institut f{\"u}r Verhaltensbiologie) ; Claudia Maletzki (Universit{\"a}tsmedizin Rostock, Medizinische Klinik III f{\"u}r H{\"a}matologie, Onkologie und Palliativmedizin) ; Sebastian Stintzing (Charit{\'e} -- Universit{\"a}tsmedizin Berlin, Medizinische Klinik mit Schwerpunkt H{\"a}matologie, Onkologie und Tumorimmunologie)",
note="Dissertation Universit{\"a}t Rostock 2023 Kumulative Dissertation",
doi="10.18453/rosdok_id00004407",
url="http://purl.uni-rostock.de/rosdok/id00004407",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00004407-6",
url="https://d-nb.info/1301016535/34",
url="https://doi.org/10.18453/rosdok_id00004407",
language="English"
}