@Book{1759758876,
author="Shang, Yuru",
title="Immunoglobulin G mediates chemoresistance to oxaliplatin in colon cancer cells by inhibiting the ERK signal transduction pathway",
year="2021",
address="Rostock",
abstract="The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Yuru Shang",
note="GutachterInnen: Dietmar Zechner (Rudolf-Zenker-Institut f{\"u}r Experimentelle Chirurgie, Zentrale Versuchstierhaltung Multimodale Kleintierbildgebung) ; Armin Wiegering (Universit{\"a}tsklinikum W{\"u}rzburg, Zentrum Operative Medizin, Klinik und Poliklinik f{\"u}r Allgemein- und Viszeralchirurgie, Gef{\"a}{\ss}- und Kinderchirurgie) ; Michael Linnebacher (Universit{\"a}tsmedizin Rostock, Molekulare Onkologie und Immuntherapie, Allgemeine Chirurgie)",
note="Dissertation Universit{\"a}t Rostock 2021",
doi="10.18453/rosdok_id00003037",
url="http://purl.uni-rostock.de/rosdok/id00003037",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00003037-4",
url="https://d-nb.info/1293663751/34",
url="https://doi.org/10.18453/rosdok_id00003037",
language="English"
}