@Book{167175865X,
author="Schwartz, Margit",
title="Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cells: role of the anti-oxidative enzyme heme oxygenase-1",
year="2018",
address="Rostock",
abstract="Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects  via an HO-1-independent mechanism.<eng>",
school="Universit{\"a}t Rostock",
note="vorgelegt von Margit Schwartz",
note="GutachterInnen: Burkhard Hinz (Universit{\"a}tsmedizin Rostock, Institut f{\"u}r Pharmakologie und Toxikologie) ; Bernhard Rauch (Universit{\"a}tsmedizin Greifswald, Institut f{\"u}r Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universit{\"a}tsmedizin Rostock, Zentrum f{\"u}r Innnere Medizin, Lehrstuhl f{\"u}r Naturheilkunde)",
note="Dissertation Universit{\"a}t Rostock 2019",
doi="10.18453/rosdok_id00002522",
url="http://purl.uni-rostock.de/rosdok/id00002522",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-rosdok_id00002522-0",
url="https://d-nb.info/1293657557/34",
url="https://doi.org/10.18453/rosdok_id00002522",
language="English"
}