@Book{1018502297,
author="Voronina, Natalia",
title="Production and characterization of genetically modified magnetized cells for future targeted treatment of cardiovascular diseases",
year="2016",
address="Rostock",
abstract="Gene therapy is a promising tool for cardiovascular disease treatment. Its wide clinical application is, however, limited by the lack of suitable targeted gene delivery systems. In this work, a non-viral vector was tested - composed by polyethyleneimine and magnetic nanoparticles (PEI/MNP) - with primary endothelial cells as in vitro model for angiogenesis and CD133+ hematopoietic stem cells. The obtained results indicate that transient genetic modification of cells with miRNA delivered by PEI/MNP is feasible and results in their magnetization sufficient for targeting and MRI detection.<eng>",
school="Universit{\"a}t Rostock",
note="submitted by Natalia Voronina",
note="Dissertation Universit{\"a}t Rostock 2017",
doi="10.18453/rosdok_id00002056",
url="http://rosdok.uni-rostock.de/resolve/urn/urn:nbn:de:gbv:28-diss2018-0050-4",
url="https://nbn-resolving.org/urn:nbn:de:gbv:28-diss2018-0050-4",
url="https://d-nb.info/1293652040/34",
url="https://doi.org/10.18453/rosdok_id00002056",
language="English"
}